Sir Alex Ferguson has ruled Nani and Darren Fletcher out of Saturday's Premier League encounter with Wolves.
The pair both picked up injuries during Tuesday evening's 3-0 win over Bursaspor in Turkey.
And whilst it is hoped the damage is not too serious, it is enough to keep two of Ferguson's most important players out of a key domestic encounter.
"Unfortunately, Nani has a groin injury and is out for Saturday," confirmed Ferguson.
"I think Darren will be out as well, so that part has been disappointing.
"It is disappointing but these things happen in football. We may have Darron Gibson back after a bout of flu but Anderson has had a virus as well and I don't think he will be ready."
Should Ferguson only be without two of his main men on Saturday, he will not regard it as too much of a price to pay.
However, with Manchester City to face at Eastlands next Wednesday, absences for any greater length of time would cause the Red Devils a huge problem.
